Cannabis for chronic pain conditions

A patient guide to the use of cannabis for chronic pain conditions

7/29/20251 min read

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Patient Guide: Cannabinoids for Chronic Pain

What Are Cannabinoids?

Cannabinoids are compounds found in the cannabis plant. The two most well-known cannabinoids are:

THC (Tetrahydrocannabinol): Produces the "high"; may help reduce pain and nausea.
CBD (Cannabidiol): Non-intoxicating; may reduce inflammation, anxiety, and certain types of pain.

They interact with the body’s endocannabinoid system, which plays a role in regulating pain, mood, and sleep.

Can Cannabinoids Help With Chronic Pain?

Research suggests that some people with chronic pain may benefit from cannabinoids, especially if other treatments haven't worked. Conditions that may respond include:

Neuropathic pain (e.g., from diabetes, nerve injury)
Arthritis
Fibromyalgia
Multiple sclerosis-related pain
Cancer-related pain

Cannabinoids may help:

Reduce pain levels
Improve sleep
Enhance quality of life

However, they don’t work for everyone.

THC vs. CBD for Pain

CBD may help reduce inflammation and mild pain with fewer side effects.
THC may help with more severe pain but can cause euphoria, dizziness, or anxiety.
Balanced THC:CBD products are often used to minimize side effects while providing pain relief.

Risks and Side Effects

Like all medications, cannabinoids can cause side effects including:

Drowsiness or fatigue
Dizziness
Dry mouth
Changes in mood or memory
Risk of dependence (mostly with high-THC use)
Interactions with other medications

Guidance from the Faculty of Pain Medicine

There is not yet enough information on whether these drugs are safe, or effective to use for long-term pain, and further research is needed urgently. Until we know more, treatments containing cannabis or cannabis-like medicines they should not be prescribed, unless a patient is taking part in a clinical study.

https://fpm.ac.uk/sites/fpm/files/documents/2021-03/Cannabis-PIL-2021.pdf

Please do not rely on this blog for medical advice. Seek advice from your doctor before starting any new medication.